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Article

Demethylator phenotypes in acute myeloid leukemia.

Leukemia - 1 Oct 2018

Kelly Andrew D, Madzo Jozef, Madireddi Priyanka, Kropf Patricia, Good Charly R, Jelinek Jaroslav, Issa Jean-Pierre J

Abstract excerpt

Acute myeloid leukemia (AML) often harbors mutations in epigenetic regulators, and also has frequent DNA hypermethylation, including the presence of CpG island methylator phenotypes (CIMPs). Although global hypomethylation is well known in cancer, the question of whether distinct demethylator phenotypes (DMPs) exist remains unanswered. Using Illumina 450k arrays for 194 patients from The Cancer Genome Atlas, we...

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Share to DNA Methylation
Share to CpG Islands
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 29556023
DOI: 10.1038/s41375-018-0084-2
PMCID: PMC6128790

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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