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Genome-wide DNA methylome analysis reveals methylation subtypes with different clinical outcomes for acute myeloid leukemia patients.

Cancer medicine - 1 Sept 2020

Gao Haiyan, He Xin, Li Qiang, Wang Ying, Tian Yaoyao, Chen Xi, Wang Jinghua, Guo Yan, Wang Wei, Li Xiaoyun

Abstract excerpt

Leukemia is the second common blood cancer after lymphoma, and its incidence rate has an increasing trend in recent years. Acute myeloid leukemia (AML) is one of the prevalent forms of leukemia. Although previous studies have investigated the methylation profile for AML patients, the AML methylation subtypes based on the genome-wide methylome are still unclear. In the present study, we identified three...

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PMID: 32628355
DOI: 10.1002/cam4.3291
PMCID: PMC7476826

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