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Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation

2026-08-27

Abstract excerpt

Autophagy dysfunction and neuroinflammation are central to Alzheimer’s disease (AD), yet how extracellular amyloid-β (Aβ) couples to impaired autophagic flux and heightened neuroinflammation remains unknown. Here, we identify the TAM receptor AXL as a molecular transducer that couples Aβ sensing to the regulation of autophagy and neuroinflammation in astrocytes. Aβ induces γ-secretase-dependent cleavage of AXL, ge...

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Literature Corpus work
f3220f53-b5fc-59f6-9f2b-056b6bd31de4
DOI
10.64898/2026.08.23.746508
Open publication

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Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammationDOI 10.64898/2026.08.23.746508
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