Article
The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease.
Science signaling - 23 Aug 2022
Zhang Zhi-Wei, Tu Haitao, Jiang Mei, Vanan Sarivin, Chia Sook Yoong, Jang Se-Eun, Saw Wuan-Ting, Ong Zhi-Wei, Ma Dong-Rui, Zhou Zhi-Dong, Xu Jie, Guo Kai-Hua, Yu Wei-Ping, Ling Shuo-Chien, Margolin Richard A, Chain Daniel G, Zeng Li, Tan Eng-King
Abstract excerpt
Gain-of-function mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are common in familial forms of Parkinson's disease (PD), which is characterized by progressive neurodegeneration that impairs motor and cognitive function. We previously demonstrated that LRRK2-mediated phosphorylation of β-amyloid precursor protein (APP) triggers the production and nuclear translocation of the APP intracellular domain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.