Article

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancer

2020-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1 , NEUROD1 , and POU2F3 (SCLC-A, -N, and -P, respectively), which are associated with distinct therapeutic vulnerabilities. To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced 54,523 cellular transcriptomes from 21 h...

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Literature Corpus work: f31f21f4-7a2d-5e53-881a-9f0f5223daf7
DOI: 10.1101/2020.12.01.406363

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