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Article

Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancer.

Cell reports. Medicine - 21 Apr 2026

Wang Zhuo, Luo Qing, Wu Jie, Lu Li, Ding Wenjie, Zhao Yichun, Yu Yongfeng, Qiu Ruoran, Zhu Ling, Ouyang Xinxing, Xuzhang Wendi, Lu Shun, Wei Wei, Shi Qihui, Li Ziming

Abstract excerpt

Combined small-cell lung cancer (cSCLC) is an aggressive subtype of SCLC with mixed histologic components. Despite heterogeneity and poorer prognosis than de novo SCLC, cSCLC is managed as SCLC because molecular insight into biology, lineage plasticity, and tumor microenvironment (TME) is limited. We perform spatial whole-exome sequencing, spatial transcriptomics, and single-nucleus RNA sequencing across 19...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41966692
DOI: 10.1016/j.xcrm.2026.102741
PMCID: PMC13130634

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