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Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

5 May 2021

Abstract excerpt

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor microenvironment together determine disease progression, as well as response to or escape from treatment. To map the cell type-specific transcriptome landscape of cancer cells and their tumor microenvironment in advanced non-small cell lung cancer (NSCLC), we analyze 42 tissue biopsy samples from stage III/IV NSCLC patients by...

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PMID: 33953163
DOI: 10.1038/s41467-021-22801-0

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