Article

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

2022-01-13

Abstract excerpt

<h4>SUMMARY</h4> The protective human antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus focuses on the spike (S) protein which decorates the virion surface and mediates cell binding and entry. Most SARS-CoV-2 protective antibodies target the receptor- binding domain or a single dominant epitope (‘supersite’) on the N terminal domain (NTD). Here, using the single B cell te...

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Literature Corpus work: 90b8f8a4-0ff1-5371-b245-7c45c84e2c97
DOI: 10.1101/2022.01.12.476120

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