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Article

An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike.

Cell reports - 25 Jun 2024

Liu Banghui, Niu Xuefeng, Deng Yijun, Zhang Zhaoyong, Wang Yanqun, Gao Xijie, Liang Huan, Li Zimu, Wang Qian, Cheng Yuanyi, Chen Qiuluan, Huang Shuangshuang, Pan Yingxian, Su Mengzhen, Lin Xiancheng, Niu Chuanying, Chen Yinglin, Yang Wenyi, Zhang Yudi, Yan Qihong, He Jun, Zhao Jincun, Chen Ling, Xiong Xiaoli

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein continues to evolve antigenically, impacting antibody immunity. D1F6, an affinity-matured non-stereotypic VH1-2 antibody isolated from a patient infected with the SARS-CoV-2 ancestral strain, effectively neutralizes most Omicron variants tested, including XBB.1.5. We identify that D1F6 in the immunoglobulin G (IgG) form is able to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38805396
DOI: 10.1016/j.celrep.2024.114265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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