Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.

doi:10.1126/science.abg5268

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Article

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.

Science (New York, N.Y.) - 4 Jun 2021

Voss William N, Hou Yixuan J, Johnson Nicole V, Delidakis George, Kim Jin Eyun, Javanmardi Kamyab, Horton Andrew P, Bartzoka Foteini, Paresi Chelsea J, Tanno Yuri, Chou Chia-Wei, Abbasi Shawn A, Pickens Whitney, George Katia, Boutz Daniel R, Towers Dalton M, McDaniel Jonathan R, Billick Daniel, Goike Jule, Rowe Lori, Batra Dhwani, Pohl Jan, Lee Justin, Gangappa Shivaprakash, Sambhara Suryaprakash, Gadush Michelle, Wang Nianshuang, Person Maria D, Iverson Brent L, Gollihar Jimmy D, Dye John M, Herbert Andrew S, Finkelstein Ilya J, Baric Ralph S, McLellan Jason S, Georgiou George, Lavinder Jason J, Ippolito Gregory C

Abstract excerpt

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor...

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Identifiers

PMID: 33947773
DOI: 10.1126/science.abg5268
PMCID: PMC8224265

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