Article

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

2020-12-21

Abstract excerpt

<h4>SUMMARY</h4> Although humoral immunity is essential for control of SARS-CoV-2, the molecular composition, binding epitopes and effector functions of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following infection are unknown. Proteomic deconvolution of the circulating IgG repertoire (Ig-Seq 1 ) to the spike ectodomain (S-ECD 2 ) in four convalescent study subjects revealed that the...

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Literature Corpus work: e3516b00-68cb-57e9-ae39-e0cf169ab0e5
DOI: 10.1101/2020.12.20.423708

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