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Article

A Method for Checking Genomic Integrity in Cultured Cell Lines from SNP Genotyping Data.

PloS one - 1 Jan 2016

Danecek Petr, McCarthy Shane A, Durbin Richard

Abstract excerpt

Genomic screening for chromosomal abnormalities is an important part of quality control when establishing and maintaining stem cell lines. We present a new method for sensitive detection of copy number alterations, aneuploidy, and contamination in cell lines using genome-wide SNP genotyping data. In contrast to other methods designed for identifying copy number variations in a single sample or in a sample...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27176002
DOI: 10.1371/journal.pone.0155014
PMCID: PMC4866717

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