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A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of <i>Orientia tsutsugamushi</i> infection

2026-05-12

Abstract excerpt

Orientia tsutsugamushi (Ot) is an obligate intracellular bacterium that causes scrub typhus, a potentially life-threatening disease. To systematically identify host factors regulating early stages of infection, we performed a microscopy-based genome-wide siRNA screen in HeLa cells. This approach identified 2,989 genes grouped into 55 functional networks that modulate bacterial entry and intracellular translocation...

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Literature Corpus work
bd7a654b-967b-5a29-bdf0-88a2f9939107
DOI
10.64898/2026.05.08.723767
Open publication

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A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of <i>Orientia tsutsugamushi</i> infectionDOI 10.64898/2026.05.08.723767
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