Article

Regulation of cell cycle by E2F1 in primary cells

2004-01-01

Abstract excerpt

Deregulation of the retinoblastoma protein (pRB) pathway is a hallmark of cancer, and in the absence of other genetic alterations, results in lack of differentiation, hyperproliferation and apoptosis. pRB acts as a transcriptional repressor by targeting the E2F transcription factors whose functions are required for S phase entry. Increased E2F activity can induce S phase in quiescent cells and this fact is a centr...

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Literature Corpus work: f2c4f6a0-0713-5acc-9ee0-46bc4d276d7f
DOI: 10.21954/ou.ro.0000f5a4

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