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Article

Role of E2F in cell cycle control and cancer

1 Jan 1998

Abstract excerpt

E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in progression through G1 and into the S-phase of the cell cycle. The activity of E2F factors is regulated through association with the retinoblastoma tumor suppressor protein (Rb) and the other pocket proteins, p107 and p130. Binding of Rb, p107 or p130 converts E2F factors from...

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Identifiers

PMID: 9556498
DOI: 10.2741/a291

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