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Article

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

25 Sept 2005

Abstract excerpt

The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the characterization of human and murine E2F8, a new member of the E2F family. Sequence analysis of E2F8 predicts the presence of two distinct E2F-related DNA binding domains suggesting that E2F8...

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Identifiers

PMID: 16179649
DOI: 10.1093/nar/gki855

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