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On the role of p53 in the cellular response to aneuploidy

1 Mar 2021

Abstract excerpt

Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest. We find that adherent 2-dimensional (2D) cultures of human immortalized or cancer cell lines activate p53 upon aneuploidy induction, whereas suspension cultures of a human...

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PMID: 33761356
DOI: 10.1016/j.celrep.2021.108892

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