Article

Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in humans and in vitro differences between genetically stratified subjects based on Interleukin-7 receptor genotype

2019-01-01

Abstract excerpt

Multiple Sclerosis is an autoimmune disease mediated by activated lymphocytes entering the central nervous system. Treatments with the greatest efficacy either prevent the entry of activated lymphocytes, or deplete the lymphocyte population, before allowing lymphocyte reconstitution. IL-7Rα was identified by genetic studies in MS pathogenesis and is involved in the homeostasis and proliferation of lymphocytes. Thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2a0a222-c33c-59de-9415-4ed6491e8a9a
DOI: 10.17863/cam.44693

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in humans and in vitro differences between genetically stratified subjects based on Interleukin-7 receptor genotypeDOI 10.17863/cam.44693Read

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.Semantic proximity Read

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.Semantic proximity Read

Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis.Semantic proximity Read

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read

IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis.Semantic proximity Read

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.Semantic proximity Read

Interleukin 7 Receptor Alpha Gene Variants Are Correlated with Gene Expression in Patients with Relapsing-remitting Multiple Sclerosis.Semantic proximity Read

The immunogenetics of multiple sclerosis.Semantic proximity Read

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.Semantic proximity Read

Multiple sclerosis treatment effects on plasma cytokine receptor levels.Semantic proximity Read

Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians.Semantic proximity Read