Article
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Lundström Wangko, Highfill Steven, Walsh Scott T R, Beq Stephanie, Morse Elizabeth, Kockum Ingrid, Alfredsson Lars, Olsson Tomas, Hillert Jan, Mackall Crystal L
Abstract excerpt
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and, thus, enhances the bioactivity of IL-7 when the cytokine is limited,...
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