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Article

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.

Nature genetics - 1 Sept 2007

Gregory Simon G, Schmidt Silke, Seth Puneet, Oksenberg Jorge R, Hart John, Prokop Angela, Caillier Stacy J, Ban Maria, Goris An, Barcellos Lisa F, Lincoln Robin, McCauley Jacob L, Sawcer Stephen J, Compston D A S, Dubois Benedicte, Hauser Stephen L, Garcia-Blanco Mariano A, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

Multiple sclerosis is a demyelinating neurodegenerative disease with a strong genetic component. Previous genetic risk studies have failed to identify consistently linked regions or genes outside of the major histocompatibility complex on chromosome 6p. We describe allelic association of a polymorphism in the gene encoding the interleukin 7 receptor alpha chain (IL7R) as a significant risk factor for multiple...

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PMID: 17660817
DOI: 10.1038/ng2103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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