Article
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Nature genetics - 1 Sept 2007
Lundmark Frida, Duvefelt Kristina, Iacobaeus Ellen, Kockum Ingrid, Wallström Erik, Khademi Mohsen, Oturai Annette, Ryder Lars P, Saarela Janna, Harbo Hanne F, Celius Elisabeth G, Salter Hugh, Olsson Tomas, Hillert Jan
Abstract excerpt
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, despite considerable...
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