Article

Multi-Omics Analysis of Red Blood Cells Reveals Molecular Pathways Underlying Thalassemia Severity Beyond Globin Gene Mutations

2025-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hemoglobinopathies are the most common monogenic genetic disorders, primarily managed through blood transfusions or bone marrow transplantation. Clinical severity other than mutational effect not well investigated and still unknown. This study aims to identify dysregulated molecular pathways in red blood cells contributing to thalassemia severity. <h4>Method</h4> From a cohort...

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Literature Corpus work: 66dd9b82-211f-5f97-82e6-5d2e98014d10
DOI: 10.1101/2025.02.09.25321939

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