Article

Inducible MLL-AF9 expression drives an AML program during human pluripotent stem cell-derived hematopoietic differentiation

2023-02-02

Abstract excerpt

<title>Abstract</title> <p>A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we generated a human inducible pluripotent stem cell (hiPSC) model with doxycycline dose-dep...

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Literature Corpus work: f283c65a-efa1-5806-b94d-2d7d13535991
DOI: 10.21203/rs.3.rs-2521405/v1

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