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MLL leukemia induction by genome editing of human CD34+ hematopoietic cells

26 Aug 2015

Abstract excerpt

Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and treatment-related leukemias and confer a poor prognosis. Studies based primarily on mouse models have substantially advanced our understanding of MLL leukemia pathogenesis, but often use supraphysiological oncogene expression with uncertain implications for human leukemia. Genome editing using site-specific nucleases...

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PMID: 26311362
DOI: 10.1182/blood-2015-05-646398

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