Article

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation

2023-11-08

Abstract excerpt

Recent studies have revealed that tRNA modification is an important epigenetic mechanism involved in gene expression. Cytosolic thiouridylase (consisting of Ctu1 and Ctu2 subunit) are the enzyme complex which catalyze the thio-modification at the 34 th wobble uridine of the anticodon of tRNAGln UUG , tRNAGlu UUC , and tRNALys UUU . Besides introducing a thiol group at the C2 positions, those tRNAs were commonl...

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Literature Corpus work: f27494d2-96d9-5ad8-ab36-0d580fb9ccac
DOI: 10.1101/2023.11.08.566201

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