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Article

Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity.

PloS one - 10 Feb 2010

Huang Haiyan, Wu Qiang

Abstract excerpt

UDP-glucuronosyltransferases (Ugts) are a supergene family of phase II drug-metabolizing enzymes that catalyze the conjugation of numerous hydrophobic small molecules with the UDP-glucuronic acid, converting them into hydrophilic molecules. Here, we report the identification and cloning of the complete zebrafish Ugt gene repertoire. We found that the zebrafish genome contains 45 Ugt genes that can be divided into...

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Identifiers

PMID: 20161780
DOI: 10.1371/journal.pone.0009144
PMCID: PMC2819257

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