Article
Pulmonary macrophage transplantation therapy.
Nature - 23 Oct 2014
Suzuki Takuji, Arumugam Paritha, Sakagami Takuro, Lachmann Nico, Chalk Claudia, Sallese Anthony, Abe Shuichi, Trapnell Cole, Carey Brenna, Moritz Thomas, Malik Punam, Lutzko Carolyn, Wood Robert E, Trapnell Bruce C
Abstract excerpt
Bone-marrow transplantation is an effective cell therapy but requires myeloablation, which increases infection risk and mortality. Recent lineage-tracing studies documenting that resident macrophage populations self-maintain independently of haematological progenitors prompted us to consider organ-targeted, cell-specific therapy. Here, using granulocyte-macrophage colony-stimulating factor (GM-CSF)...
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