Article

Targeting pulmonary fibrosis with DDR2-specific chimeric antigen receptor macrophages

2026-01-29

Abstract excerpt

<title>Abstract</title> <p> Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a critical unmet need in therapeutic options. Chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) have shown potential for IPF, but other cell-based approaches remain under-explored. In this study, we generated CAR macrophages (DDR2-CARM) targeting DDR2, a collagen receptor specifically upreg...

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Literature Corpus work: 2f78849d-869c-5c38-9c1c-ae11a3bed301
DOI: 10.21203/rs.3.rs-8675185/v1

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