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Article

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2024

Fernandez-Gonzalez Angeles, Mukhia Amit, Nadkarni Janhavi, Willis Gareth R, Reis Monica, Zhumka Kristjan, Vitali Sally, Liu Xianlan, Galls Alexandra, Mitsialis S Alex, Kourembanas Stella

Abstract excerpt

BACKGROUND: Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at treating vascular remodeling are lacking. We aimed to evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/proresolving phenotype in attenuating early pulmonary inflammation and progression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39387119
DOI: 10.1161/ATVBAHA.124.321264
PMCID: PMC11697987

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