Article
Murine Ex Vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function.
American journal of respiratory cell and molecular biology - 1 Jan 2022
Gorki Anna-Dorothea, Symmank Dörte, Zahalka Sophie, Lakovits Karin, Hladik Anastasiya, Langer Brigitte, Maurer Barbara, Sexl Veronika, Kain Renate, Knapp Sylvia
Abstract excerpt
Tissue-resident macrophages are of vital importance as they preserve tissue homeostasis in all mammalian organs. Nevertheless, appropriate cell culture models are still limited. Here, we propose a novel culture model to study and expand murine primary alveolar macrophages (AMs), the tissue-resident macrophages of the lung, in vitro over several months. By providing a combination of granulocyte-macrophage...
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