Article
Integrative genomic strategies applied to a lymphoblast cell line model reveal specific transcriptomic signatures associated with clozapine response
2020-09-22
Abstract excerpt
Clozapine is an important antipsychotic drug. However, its use is often accompanied by metabolic adverse effects and, in rare instances, agranulocytosis. The molecular mechanisms underlying these adverse events are unclear. To gain more insights into the response to clozapine at the molecular level, we exposed lymphoblastoid cell lines (LCLs) to increasing concentrations of clozapine and measured genome-wide gene...
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Identifiers and source
- Literature Corpus work
- f250511d-86f6-5f64-8459-4ba98506cab8
- DOI
- 10.1101/2020.09.22.308262