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Article

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Mar 2024

Kappel Djenifer B, Rees Elliott, Fenner Eilidh, King Adrian, Jansen John, Helthuis Marinka, Owen Michael J, O'Donovan Michael C, Walters James T R, Pardiñas Antonio F

Abstract excerpt

Clozapine is the only licensed medication for treatment-resistant schizophrenia (TRS). Few predictors for variation in response to clozapine have been identified, but clozapine metabolism is known to influence therapeutic response and adverse side effects. Here, we expand on genome-wide studies of clozapine metabolism, previously focused on common genetic variation, by analysing whole-exome sequencing data from...

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Identifiers

PMID: 38310750
DOI: 10.1016/j.euroneuro.2023.12.007
PMCID: PMC7619122

Genes

CYP1A2
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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