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Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts

2023-11-17

Abstract excerpt

The second-generation antipsychotic clozapine is used as a medication for treatment-resistant schizophrenia. It has previously been associated with epigenetic changes in pre-clinical rodent models and cross-sectional studies of treatment-resistant schizophrenia. Cross-sectional studies are susceptible to confounding, however, and cannot disentangle the effects of diagnosis and medication. We therefore profiled DNA...

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Literature Corpus work
04c0f701-37bf-554b-9dc9-e3491a30fb91
DOI
10.1101/2023.11.17.23298669
Open publication

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Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohortsDOI 10.1101/2023.11.17.23298669
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