Modulation of Recovery from Neonatal Hyperoxic Lung Injury by Sex as a Biological Variable

Abstract excerpt

<h4>ABSTRACT</h4> Recovery from lung injury during the neonatal period requires the orchestration of many biological pathways. The modulation of such pathways can drive the developing lung towards proper repair or persistent maldevelopment that can lead to a disease phenotype. Sex as a biological variable can regulate these pathways differently in the male and female lung exposed to neonatal hyperoxia. In this st...

Topics

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• Bronchopulmonary Dysplasia
• Congenital Diaphragmatic Hernia Studies
• Congenital heart defects research
• Epigenetics and DNA Methylation
• Genotype
• Hyperoxia
• Neonatal Respiratory Health Research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

f24dab76-868e-55cc-8b9c-12a3e8c455df

DOI

10.1101/2023.08.09.552532