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Article

Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage.

Nature communications - 10 Mar 2021

Hurskainen Maria, Mižíková Ivana, Cook David P, Andersson Noora, Cyr-Depauw Chanèle, Lesage Flore, Helle Emmi, Renesme Laurent, Jankov Robert P, Heikinheimo Markku, Vanderhyden Barbara C, Thébaud Bernard

Abstract excerpt

During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33692365
DOI: 10.1038/s41467-021-21865-2
PMCID: PMC7946947

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