Article

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasia

2022-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Hyperoxia (HOX) disrupts lung development in mice and causes bronchopulmonary dysplasia (BPD) in neonates. To investigate sex-dependent molecular and cellular programming involved in HOX, we surveyed the mouse lung using single cell RNA sequencing (scRNA-seq), and validated our findings in human neonatal lung cells in vitro . HOX-induced inflammation in alveolar type (AT) 2 cells gave rise to d...

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Literature Corpus work: 6334881f-9652-51d9-9ad1-9d17e2440ffa
DOI: 10.1101/2022.07.12.499826

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