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Article

Remarkable sex-specific differences at single-cell resolution in neonatal hyperoxic lung injury

25 Oct 2022

Abstract excerpt

Exposure to supraphysiological concentrations of oxygen (hyperoxia) predisposes to bronchopulmonary dysplasia (BPD), which is characterized by abnormal alveolarization and pulmonary vascular development, in preterm neonates. Neonatal hyperoxia exposure is used to recapitulate the phenotype of human BPD in murine models. Male sex is considered an independent predictor for the development of BPD, but the main...

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PMID: 36283964
DOI: 10.1152/ajplung.00269.2022

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