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Article

Role of sex as a biological variable in neonatal alveolar macrophages

2 Aug 2024

Abstract excerpt

The lung macrophages play a crucial role in health and disease. Sexual dimorphism significantly impacts the phenotype and function of tissue-resident macrophages. The primary mechanisms responsible for sexually dimorphic outcomes in bronchopulmonary dysplasia (BPD) remain unidentified. We tested the hypothesis that biological sex plays a crucial role in the transcriptional state of alveolar macrophages, using...

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PMID: 39098263
DOI: 10.1016/j.redox.2024.103296

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