Article

Lack of pattern decorrelation in the prelimbic circuit disables social discrimination in Mecp2-deficient mice

2020-12-02

Abstract excerpt

<title>Abstract</title> <p>The prefrontal cortical (PFC) circuit plays a central role in processing social information. PFC dysfunction has been demonstrated in many autism-associated disorders, including Rett syndrome (RTT), which is caused by loss-of-function mutations in the X-linked gene MECP2. The prelimbic PFC is hypoactive in RTT, but the precise mechanisms underlying the social avoidance remain obscure. H...

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Literature Corpus work: f234a7c8-7d02-5f71-a5f0-3c754125084c
DOI: 10.21203/rs.3.rs-112145/v1

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