Article

mPFC pyramidal neuron synchrony during social competition to form social rankings is disrupted in male Mecp2 knockout mice

2026-03-04

Abstract excerpt

Altered social behaviors are prevalent in neurodevelopmental disorders like monogenic Rett syndrome, which is caused by pathogenic variants in the gene encoding the methylated DNA binding transcriptional regulator MeCP2. Monosynaptic projections from the ventral hippocampus to the medial prefrontal cortex (mPFC) modulate social memory, and are altered in male Mecp2 knockout (KO) mice. The standard tube test was us...

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Literature Corpus work: beaafbbd-f8e9-5822-847e-27db42bf5c6b
DOI: 10.64898/2026.03.02.709145

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