Article

Structure and mechanism of the RalGAP tumor suppressor complex

2024-11-25

Abstract excerpt

The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus crucial components that counteract (oncogenic) Ras signaling. However, no structural information on the architecture of this tumor suppressor complex is available hampering a mechanistic understanding of its functionality. Here, we present a cryo-EM structure of RalGAP that reveals an extended 58 nm tetrameric arch...

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Literature Corpus work: f2348639-44bb-5bd5-9f09-d899ce8c73b5
DOI: 10.1101/2024.11.25.625123

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