Article
Ral signaling pathway in health and cancer.
Cancer medicine - 1 Dec 2017
Moghadam Adel Rezaei, Patrad Elham, Tafsiri Elham, Peng Warner, Fangman Benjamin, Pluard Timothy J, Accurso Anthony, Salacz Michael, Shah Kushal, Ricke Brandon, Bi Danse, Kimura Kyle, Graves Leland, Najad Marzieh Khajoie, Dolatkhah Roya, Sanaat Zohreh, Yazdi Mina, Tavakolinia Naeimeh, Mazani Mohammad, Amani Mojtaba, Ghavami Saeid, Gartell Robyn, Reilly Colleen, Naima Zaid, Esfandyari Tuba, Farassati Faris
Abstract excerpt
The Ral (Ras-Like) signaling pathway plays an important role in the biology of cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic effectors. Our team has demonstrated the overactivation of the RalA signaling pathway in a number of human malignancies including cancers of the liver, ovary, lung, brain, and malignant peripheral nerve sheath tumors. Additionally, we have shown...
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