G12 mutations rewire allosteric communication at the Ras-RalGDS interface.

Abstract excerpt

The Ras subfamily is the most extensively studied branch of the Ras superfamily, with 20% of all human tumors having activating mutations in one of the RAS genes. Recent studies have shown that the Ras/RalGDS/Ral pathway plays a more significant role in the progression of Ras-driven colon and pancreatic cancers than the Ras/Raf and Ras/PI3K pathways. In this study, we investigated the interaction between Ras and...

Topics

• Molecular Dynamics Simulation
• Mutation
• Allosteric Regulation
• ral Guanine Nucleotide Exchange Factor
• ras Proteins
• Protein Binding