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Article

Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex

2 Dec 2019

Abstract excerpt

Our primary goal is to therapeutically target the oncogenic transcription factor MYC to stop tumor growth and cancer progression. Here, we report aspects of the biophysical states of the MYC protein and its interaction with one of the best-characterized MYC cofactors, TRansactivation/tRansformation-domain Associated Protein (TRRAP). The MYC:TRRAP interaction is critical for MYC function in promoting cancer. The...

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PMID: 31790487
DOI: 10.1371/journal.pone.0225784

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