Article

Structural insights into the complex of oncogenic KRas4B <sup>G12V</sup> and Rgl2, a RalA/B activator

2022-10-10

Abstract excerpt

About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs), play an essential role in oncogenic Ras-induced signalling. We studied the interaction between human KRas4B and the Ras association (RA) domain of Rgl2 (Rgl2 RA ), one of the RA-containing RalGEFs. We show...

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Literature Corpus work: e87c8e78-71b0-5b95-b787-d8eba86dd2ce
DOI: 10.1101/2022.10.10.511529

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