Article

Identifying potential macrophage polarization-related causal genes in sepsis through multi-omics mendelian randomization analysis and experimental validation

2026-08-22

Abstract excerpt

The genetic associations between macrophage polarization-related genes (MPGs) and sepsis remain unclear. This study aimed to identify sepsis-associated MPGs. Based on blood-derived methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data for 731 MPGs identified from the GeneCards database, this study employed a summary-data-based Mendelian randomization (SMR) design to investi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f22cc34d-b7dc-569e-bf13-d271748d353b
DOI: 10.1186/s13148-026-02231-9

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying potential macrophage polarization-related causal genes in sepsis through multi-omics mendelian randomization analysis and experimental validationDOI 10.1186/s13148-026-02231-9Read

Identification and validation of potential genes for the diagnosis of sepsis by bioinformatics and 2-sample Mendelian randomization studySemantic proximity Read

Mitochondrial related genome-wide mendelian randomization identifies putatively causal genes in the pathogenesis of sepsisSemantic proximity Read

Mitochondrial-related genome-wide Mendelian randomization identifies putatively causal genes in the pathogenesis of sepsisSemantic proximity Read

Landscape of multiple tissues' gene expression pattern associated with severe sepsis: Genetic insights from Mendelian randomization and trans-omics analysis.Semantic proximity Read

Identification of circulating inflammatory proteins as potential drug targets for sepsis through Mendelian randomization and colocalization analyses.Semantic proximity Read

Using Mendelian randomization provides genetic insights into potential targets for sepsis treatmentSemantic proximity Read

Integration of Mendelian Randomization to Explore the Genetic Influences of Pediatric Sepsis: A Focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2Semantic proximity Read

Integrative Mendelian randomization reveals the mediating role of immune cell traits in the causal pathway from gene expression to neonatal bacterial sepsis.Semantic proximity Read

Circulating inflammatory cytokines and the risk of sepsis: a bidirectional mendelian randomization analysis.Semantic proximity Read

Causal association of immune effector proteins with sepsis: A Mendelian randomization study.Semantic proximity Read

Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2.Semantic proximity Read

[Causal association between immune cells and sepsis: a based on Mendelian randomization method study].Semantic proximity Read