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Article

Integrative Mendelian randomization reveals the mediating role of immune cell traits in the causal pathway from gene expression to neonatal bacterial sepsis.

Medicine - 24 Apr 2026

Liang Jing, Wei Rong, Yi Wei, Chen Junchang, Li Dongxiao, Xiao Lin, Lai Qiuru, Fang Qiuting, Lü Jibao, Wei Yingcai, Yuan Jiaquan, Gan Junhong

Abstract excerpt

Neonatal bacterial sepsis (NBS) remains a major global burden. Although immune dysfunction is central to its pathogenesis, the causal contribution of specific immune cell phenotypes and their upstream genetic regulation is unclear. This study aimed to test whether genetically predicted gene expression influences NBS risk through immune cell traits using an integrative two-step Mendelian randomization (MR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42071849
DOI: 10.1097/MD.0000000000048476
PMCID: PMC13124360

Genes

CD28
SNCA
TRPM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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