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Article

Potential mitochondria-associated pathogenic genes in sepsis: a multi-omics Mendelian randomization study.

Frontiers in immunology - 1 Jan 2026

Wang Lu, Gao Zhen, Wang Chengjin, Zhao Yan, Deng Zihui, Bai Yang, Yang Mengmeng, Zou Yuhang, Kang Hongjun

Abstract excerpt

Background: Mitochondrial dysfunction has been implicated in the pathophysiology of sepsis. However, human genetic evidence linking mitochondria-related genes to sepsis susceptibility remains limited. This study aimed to identify mitochondria-related genes associated with sepsis risk using a multi-omics Mendelian randomization framework. Methods: Summary-data-based Mendelian randomization (SMR) was applied using...

Read the complete abstract on PubMed

Topics

Humans
Sepsis
Mendelian Randomization Analysis
Quantitative Trait Loci
Genome-Wide Association Study
Multiomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Mitochondria

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42694092
DOI: 10.3389/fimmu.2026.1881375
PMCID: PMC13538090

Genes

AK4
DUT
PPOX
SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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