Landscape of multiple tissues' gene expression pattern associated with severe sepsis: Genetic insights from Mendelian randomization and trans-omics analysis.

Abstract excerpt

BACKGROUND: Sepsis, a systemic syndrome often culminating in multiple organ failure (MOF), poses a substantial global health threat. However, the gene expression pattern of various tissues associated with severe sepsis remains elusive. METHODS: Applying the summary data-based Mendelian randomization (SMR) method, we integrated sepsis genome-wide association study (GWAS) data and expression quantitative trait loci...

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• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Mice
• Quantitative Trait Loci