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Article

Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2.

BMC pediatrics - 27 Jan 2025

Zhang Liuzhao, Chu Quanwang, Jiang Shuyue, Shao Bo

Abstract excerpt

OBJECTIVE: This study aims to explore the genetic characteristics of pediatric sepsis through a combined analysis of multiple methods, including Mendelian Randomization (MR), differential gene expression analysis, and immune cell infiltration assessment. It explores their potential as biomarkers for sepsis risk and their involvement in immune-related pathways. METHODS: Differential expression analysis was...

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Child
Child, Preschool
DEAD-box RNA Helicases
GTPase-Activating Proteins
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondrial Proton-Translocating ATPases

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39871218
DOI: 10.1186/s12887-025-05424-y
PMCID: PMC11770931

Genes

ATP9A
MAP3K7CL
RGL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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